Phagocytosis without inflammation

Phagocytosis without inflammation

Thymocytes must pass a series of checkpoints on the road to becoming mature T cells. On page 603, Mandal et al. show that cells use Bcl2A1, a member of the Bcl2 family of survival proteins, to pass one critical checkpoint. The cell cannot make substitutes for this protein in a pinch, revealing that Bcl2A1 may be uniquely specialized for promoting survival without suppressing proliferation. To b...

Macrophage Phagocytosis of Aging Neutrophils in Inflammation

Mechanisms governing the normal resolution processes of inflammation are poorly understood, yet their elucidation may lead to a greater understanding of the pathogenesis of chronic inflammation. The removal of neutrophils and their potentially histotoxic contents is one prerequisite of resolution. Engulfment by macrophages is an important disposal route, and changes in the senescent neutrophil ...

Healing without inflammation?

ISCHEMIA FOLLOWED BY REPERFUSION, traumatic injury, muscle unloading followed by reloading, or many other types of injury result in a vigorous inflammatory response followed by eventual healing or ultimate demise of the damaged tissue. The inflammatory response is characterized by neutrophil infiltration, which is often associated with significant additional tissue damage beyond the injury infl...

Phagocytosis: Implications for Malaria CD36 and TLR Interactions in Inflammation

Erosions rare without clinically detectable inflammation.